Importance of H-FABP in Early Diagnosis of Acute Myocardial Infarction
Authors: Andreea Licuta Pavel, Nilima Rajpal Kundnani, Stelian I Morariu, et al.
Journal: International Journal of General Medicine, 2024
Conclusion:
H-FABP demonstrated higher sensitivity and specificity in early myocardial infarction detection, particularly within the first 4 hours of chest pain onset, compared to traditional biomarkers. Incorporating H-FABP into diagnostic protocols could enhance early detection and treatment of AMI, potentially reducing mortality and healthcare costs.
Methods:
This study included 83 patients presenting with suspected coronary events between August 2020 and June 2021. Patients were divided into two groups:
- Group 1: First medical contact within 4 hours of chest pain onset
- Group 2: First medical contact after 4 hours.
H-FABP levels, along with hsTni and CK-MB, were measured. Statistical analysis was performed using MedCalc, with p < 0.05 considered significant. Sensitivity and specificity were compared between the two groups.
Results:
- Group 1 (within 4 hours):
- H-FABP sensitivity: 89.67%
- H-FABP specificity: 95.65%
- H-FABP outperformed hsTni and CK-MB in early diagnosis.
- Group 2 (after 4 hours):
- H-FABP sensitivity: 86.73%
- H-FABP specificity: 49.84%
- hsTni had higher specificity (69.98%) in later presentations.