Association Between Platelet-to-Lymphocyte Ratio and In-hospital Mortality in Elderly Patients with Severe Trauma
Authors: Ji Ho Lee, Dong Hun Lee, Byung Kook Lee
Published in: Western Journal of Emergency Medicine, 2024 January
Conclusion:
- Low platelet-to-lymphocyte ratio is independently associated with increased in-hospital mortality in elderly patients with severe trauma.
Methods:
- Retrospective observational study of elderly patients (aged ≥65 years) admitted for severe trauma (Injury Severity Score [ISS] ≥16) between January and December 2022.
- Utilized multivariate logistic regression analysis to assess the association between PLR and in-hospital mortality, controlling for relevant covariates.
- Conducted receiver operating characteristic curve analysis to evaluate PLR's prognostic performance.
Results:
- The study included 222 patients, with an in-hospital mortality rate of 19.4% (43 patients).
- Non-survivors had a lower PLR compared to survivors (62.1 vs 124.5).
- The areas under the curve (AUC) for predicting in-hospital mortality were:
- Glasgow Coma Scale (GCS) score ≤12: 0.730 (95% CI 0.667-0.787)
- ISS: 0.771 (95% CI 0.710-0.824)
- Hemoglobin level: 0.657 (95% CI 0.591-0.719)
- PLR: 0.730 (95% CI 0.667-0.788)
- PLR's AUC was comparable to GCS score ≤12 and ISS for predicting in-hospital mortality.
- Multivariate analysis indicated an independent association between PLR and in-hospital mortality (odds ratio: 0.993; 95% CI 0.987-0.999).